High-Intensity Training Following Lung Transplantation
- Conditions
- Lung TransplantExercise Training
- Registration Number
- NCT03155074
- Lead Sponsor
- Oslo University Hospital
- Brief Summary
The HILT study is a prospective, single-blinded, randomized controlled trial comparing a high-intensity exercise training intervention with usual care among adult lung transplant recipients. Patients randomized to the training intervention arm will undergo individually tailored high-intensity exercise training (80-95% of maximum heart rate) three hours per week for 20 weeks. Training will be conducted at local fitness centers on a one-on-one basis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 54
- Stable medical condition in the opinion of the enrolling investigator
- Able and willing to give informed consent
- Expected survival less than 12 months
- Unable to complete a maximal exercise test on a treadmill until exhaustion
- Language barrier that interferes with data collection
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Change in peak oxygen uptake 0-20 weeks Measured by cardiopulmonary exercise test
- Secondary Outcome Measures
Name Time Method Change in total body composition (fat, muscle and bone mass) 0-20 weeks Measured by dual-energy x-ray absorptiometry (DEXA)
Change in upper body strength 0-20 weeks Measured by maximum breast press
Change in forced expiratory volume in one second (FEV1) 0-20 weeks Measured by spirometry
Change in leg strength 0-20 weeks Measured by maximum leg press
Change submaximal exercise capacity 0-20 weeks Measured by 6-minute walk distance
Change in hand strength 0-20 weeks Measured by grip strength dynamometer
Change in health-related quality of life 0-20 weeks Measured by Short Form 36 (SF-36)
Trial Locations
- Locations (1)
Oslo University Hospital
🇳🇴Oslo, Norway
Oslo University Hospital🇳🇴Oslo, Norway