Biomarker Assessment in Heart Failure with Reduced Systolic Function (HFrEF) and Preserved Systolic Function (HFpEF)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Atrial Fibrillation (AF)
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
- Enrollment
- 114
- Locations
- 2
- Primary Endpoint
- Evaluation of FAR
- Status
- Not yet recruiting
- Last Updated
- last year
Overview
Brief Summary
Systemic inflammation is closely associated with the development and progression of heart failure (HF). The study assessed the fibrin/albumin (FAR) ratio, a very important biomarker, as a prognostic indicator of HE. Study population is composed by patients who were addicted with heart failure diagnosed for the first time or already under treatment (NYHA class II-IV) and reduced ejection fraction (HFrEF) or preserved ejection fraction (HFpEF).
Detailed Description
Prospective, observational, single-center study, which involves the enrollment of patients affected by heart failure of first diagnosis or already in therapy, who will be subjected to an analysis of the Albumin/fibrinogen ratio. Subjects will not be subjected to specific visits or services for the study: clinical and anamnestic data will be collected during routine visits.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients ≥ 18 years
- •Patients with newly diagnosed or already treated heart failure (NYHA class II-IV) with HFrEF and HFpEF with and without atrial fibrillation.
- •Patients who sign the consent to participate in the study
Exclusion Criteria
- •Patients with infectious/autoimmune diseases, neoplasms, liver failure, renal failure (Cl creatinine \< 30 mL/L), structural cardiomyopathies and pericarditis.
- •Pregnant/breastfeeding women (verified by self-declaration)
Outcomes
Primary Outcomes
Evaluation of FAR
Time Frame: At Hospital admission
Evaluate FAR (=Fibrin/Albumin) in heart failure HFrEF and HFpEF with or without atrial fibrillation.
Secondary Outcomes
- FAR (=Fibrinogen/Albumin) and functional ultrasound(At Hospital admission and at hospital discharge (assessed up to 1 months))