NCT02776384招募中不适用
Prognostic and Diagnostic Value of Serial Biomarker Measurements, Echocardiographic Techniques and Cardiopulmonary Function Tests in Patients With Chronic Heart Failure.
Shanghai Jiao Tong University School of Medicine1 个研究点 分布在 1 个国家目标入组 1,000 人开始时间: 2015年12月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- cardiovascular mortality
研究概览
简要总结
The study aims to investigate whether disease progression in patients with chronic heart failure (CHF) can be assessed by new biomarkers, and determine their diagnostic value. The study also intends to describe comparison of echocardiography with cardiopulmonary function test in CHF patients, and relating these cardiac functional parameters to clinical outcome.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years
- •with symptoms and signs in NYHA Ⅱ~Ⅳ
- •with cardiac structural changes confirmed by echocardiography
排除标准
- •with other severe diseases combined and will be alive for less than 12 months
- •hard to participate in the investigation or accept the follow-up visits
- •pregnant or lactating women
- •during the acute phase of ST-elevation acute myocardial infarction, stroke, severe infection and other critical conditions
结局指标
主要结局
cardiovascular mortality
时间窗: 10 years
main adverse cardiovascular and cerebrovascular events, MACCE
时间窗: 10 years
MACCE includes all-cause mortality, cardiovascular mortality, nonfatal myocardial infarction, nonfatal stroke, target lesion revascularization and HF rehospitalization
次要结局
- new stroke(10 years)
- heart failure rehospitalization(10 years)
- quality of life(10 years)
- worsening of renal function(10 years)
- all-cause mortality(10 years)
- new myocardial infarction(10 years)
研究者
Zhang Qi, MD
MD
Shanghai Jiao Tong University School of Medicine
研究点 (1)
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