Addition of Prednisolone and Heparin in Patients Undergoing IVF With Failed IVF Cycles
Phase 2
Completed
- Conditions
- Infertility
- Interventions
- Drug: COH for IVF
- Registration Number
- NCT01590173
- Lead Sponsor
- National and Kapodistrian University of Athens
- Brief Summary
The addition of heparin and prednisolone increases pregnancy outcome parameters in women undergoing In Vitro Fertilisation (IVF) with failed IVF cycles.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 86
Inclusion Criteria
- personal history of ≥2 failed IVF/ICSI cycles
- age <45 years
- availability of fresh ejaculate sperm for IVF/ICSI procedures
- confirmation of normal uterine cavity
- presence of good quality (Grade I or II) embryos for transfer
Exclusion Criteria
- endocrine disorders
- immune disorders
- coagulation disorders
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Prednisolone and Heparin during COH for IVF Prednisolone and Heparin during COH for IVF - COH for IVF COH for IVF -
- Primary Outcome Measures
Name Time Method clinical pregnancy rate finding of a fetal heart at >6 gestational weeks / 2 years
- Secondary Outcome Measures
Name Time Method miscarriage rate through study completion, an average of 2 years live birth rate through study completion, an average of 2 years OHSS through study completion, an average of 2 years multiple pregnancy rate through study completion, an average of 2 years biochemical pregnancy rate through study completion, an average of 2 years
Trial Locations
- Locations (1)
Assisted Reproduction Unit, 3rd Department of Obstetrics & Gynecology
🇬🇷Athens, Chaidari, Attica, Greece