Effect of diease-modifying and biological drugs on intestinal immunity in patients with rheumatoid arthritis. - Anti-rheumatic drugs, biologicals and intestinal immunity.

Patients of Rheumatoid arthritis(RA), dividing into two pathogenisis of rapid rediographic progression(RRP) and non-RRP, were assyed for their IgA and IgG antibody activity to E coli-LPS, Gingivalis LPS and St. pyogenes PG-PS and compared with those of normal person. No significant differenses was obserbed between RA and normal. Correlation between RA disease markers,RF, ESR, CRP and also DAS28-ESR to an anti IgA/IgG ratio of Pg-LPS correlated in RRP. In contrast,the ratio to E. coli-LPS and also PG-PS correlated with the disease markers in non-RRP. Results shwed that multiple embironmental pathogen, which overwhelm the host antibody defense function, cotribute independently or concomitantly to evoking disease markers and aggravationg disease activity, and affect disease outcomes.