Apitoxin Versus Soft Laser for Management of Aphthous Ulceration
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Ulcer Surface Area
研究概览
简要总结
The current study evaluated the clinical effect and outcome of locally applied bee venom versus low-level laser therapy (LLLT) for the treatment of recurrent aphthous ulceration.
详细描述
Recurrent aphthous stomatitis (RAS) is a Painful, idiopathic, and recurrent inflammatory ulceration of the oral cavity.
Despite their widespread use, prolonged or frequent application may result in adverse effects such as oral candida. In recent years, low-level laser therapy (LLLT) has gained attention as an alternative treatment for RAS.
Apitoxin has been used traditionally to treat a variety of conditions, such as arthritis, rheumatism, back pain, cancer, and skin diseases.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 15 Years 至 40 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age from 15 to 40 years old.
- •Both sexes.
- •No current or history of systemic medical problem.
- •Non-smoker.
- •Suffering from pain due to recurrent aphthous stomatitis (RAS) ulceration on the oral mucosa with the following characteristics:
- •Duration of 2 days or less.
- •The diameter ≥ 4mm
- •Not been subjected to any treatment modalities for at least four weeks before the beginning of the study.
排除标准
- •Presence of other oral mucosal ulcers other than RAS.
- •Systemic disease that predisposed them to RAS (e.g., Behçet disease).
- •Systemic medical problems.
- •Pregnant, lactating, and postmenopausal patients.
- •Smoker patients.
- •Systemic or topical treatment for RAS less than four weeks before starting the study.
- •Any earlier experiences of laser therapy.
研究组 & 干预措施
Group Ӏ
Patients managed by Low-level laser therapy (LLLT).
干预措施: Low-level laser therapy (LLLT) (Device)
Group II
Patients managed with 0.3% Apitoxin Gel.
干预措施: Apitoxin (Drug)
结局指标
主要结局
Ulcer Surface Area
时间窗: 5 days post-treatment
Ulcer Surface Area: The main outcome will be the objective measurement of the ulcer surface area. This was evaluated through photographs taken on Day 1 (baseline) and Day 5 (post-treatment).
次要结局
- Pain Sensation(5 days post-treatment)
- Effectiveness Index (EI)(5 days post-treatment)
研究者
Mohamed Omar Elboraey Elbal
Assistant Professor of Oral Medicine, Periodontology, Oral Diagnosis and Oral Radiology Department, Faculty of Dentistry, Tanta, University, Tanta, Egypt
Tanta University