Healthy Diets for a Healthy Weight: Exploring Physiological Mechanisms Related to Dietary Fibre
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Appetitive Behavior
- Sponsor
- University of Aberdeen
- Enrollment
- 7
- Locations
- 1
- Primary Endpoint
- Change in gut hormones to assess appetite response to dietary fibre
- Status
- Terminated
- Last Updated
- last year
Overview
Brief Summary
The investigators present a diet intervention study, to be conducted as a within-subject design, with all food and beverages provided, to allow ad libitum feeding to assess impact of diet change on appetite response. The diets will vary in fibre content and type. This study will allow assessment of the physiological impact of dietary fibre on markers of appetite control for body weight, measured from plasma gut hormones. The investigators propose to recruit participants with a poor diet quality (low habitual fibre intake) to additionally examine the time-course of adaptation of the gut microbiome (measured in faecal samples), whilst assessing the impact of added fibre on body weight and subjective appetite scores. This approach is to address the impact of dietary fibre in people living with obesity and food inequalities. The investigators will assess physiological bio-markers of appetite control and their contribution to the development of a gut ecosystem that promotes health. A subsequent period of return to a low fibre feeding will allow assessment of durability of response.
Investigators
Eligibility Criteria
Inclusion Criteria
- •healthy but overweight/obese (BMI 28-40kg/m2) males and females (post-menopausal, using the oral contraceptive pill or some form of hormonal contraceptive)
- •low habitual fibre intake (\<10g/day)
Exclusion Criteria
- •Medication exclusion criteria:
- •antibiotic use (within the past 3 months due to impact on gut microbiota)
- •statins (current)
- •aspirin or other NSAIDs or anti-coagulants (current)
- •anti-depressants (current)
- •smoking or vaping
- •Medical exclusion criteria:
- •Females who are planning to be pregnant, are pregnant or are breastfeeding
- •Anyone with food allergies, self-reported food sensitivity or intolerance
- •Anyone with coeliac disease or gluten intolerance
Outcomes
Primary Outcomes
Change in gut hormones to assess appetite response to dietary fibre
Time Frame: At baseline and end of each arm (study days 0, 14, 28 and 42)
measured by acute and chronic changes in plasma ghrelin and peptide YY (PYY)
Change in subjective hunger to assess appetite response to dietary fibre
Time Frame: At baseline and end of each arm (study days 0, 14, 28 and 42)
measured by acute and chronic changes in appetite using visual analogue scale questionnaires
Secondary Outcomes
- Change in gut metabolites (from faecal samples) in response to dietary fibre(At baseline and end of each arm (study days 0, 14, 28 and 42))
- Change in gut microbiome composition (from faecal samples) in response to dietary fibre(At baseline and end of each arm (study days 0, 14, 28 and 42))
- Change in glycaemic control in response to dietary fibre(At baseline and end of each arm (study days 0, 14, 28 and 42))