Psychotherapy in Social Anxiety Disorder and Alterations in Neural Processing (PANDA)

Not Applicable

Conditions: F40.1
Social phobias

Registration Number: DRKS00023863

Lead Sponsor: AB Klinische Psychologie und Psychotherapie, FB Erziehungswissenschaft und Psychologie, Freie Univerisät Berlin

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 160

Inclusion Criteria

The study will be conducted with 18-65 year old participants, diagnosed with social anxiety disorder (F40.1). Social anxiety disorder will be diagnosed via the structured clinical interview I for DSM-5 (SCID-I). Healthy control participants will be aged 18-65 and will not meet diagnostic criteria for any mental disorder.

Exclusion Criteria

Following exclusion criteria will be applied: Current severe depressive episode with or without psychotic symptoms (F32.2, F32.3, F33.2 or F33.3), current Borderline or Antisocial personality disorder, acute suicidality, acute or lifetime schizophrenia, delusional disorder (F2x.x) or bipolar disorder (F31.x), current substance addiction (alcohol, heroin, amphetamine, cocaine: minimum abstention 12 months), current severe neurological disorder of the central nervous system, chronic obstructive pulmonary disease (COPD), coronary artery disease, heart insufficiency, anemia, body mass index >30 or <18, language problems, non-correctable viewing or hearing limitations.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in underlying psychological and biological mechanisms during a social-evaluative situation, comparing patients after group therapy vs. waitlist: BOLD-signal, working memory performance, electrodermal activity, heart rate, subjective stress ratings.

Secondary Outcome Measures

Name	Time	Method
Changes in underlying neurobiological mechanisms a) during a negative self-belief task, b) during an emotional faces task, and c) during an fMRI resting state measurement, comparing patients after group therapy vs. waitlist. <br>Saliva cortisol; <br>Electrodermal activity and heart rate during a behavioral experiment measuring near-miss inference. <br>Additional questionnaires: <br>BSI (Brief Symptom Inventory)<br>SPIN (Social Phobia Inventory)<br>SIAS (Social Interaction Anxiety Scale)<br>ASI-3 (Anxiety Sensitivity Index)<br>BDI-2 (Beck’s Depression Inventory)<br>PSS-10 (Perceived Stress Scale)<br>DERS (Difficulties in Emotion Regulation Scale)<br>PASA (Primary Appraisal, Secondary Appraisal)<br>SWE (Self Efficacy Scale)<br>MDBF (Multidimensional Questionnaire on Mental State)