Hypothalamic serotonin transporters in subjects suspect for hypothalamic damage
- Conditions
- hypothalamic damagehypothalamic dysfunction10021112
- Registration Number
- NL-OMON36631
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 18
Inclusion Criteria
having pituitary insufficiency and suspicion of hypothalamic damage
or having pituitary insufficiency and no suspicion of hypothalamic damage
or (in case of controls) being healthy
age between 18-75 years old
Exclusion Criteria
*Unwilling or unable to provide informed consent
*Serious neuropsychiatric problems
*Use of medication which interferes with serotonin metabolism (e.g. psychotropic medication like SSRIs or other antidepressants) and dopamin metabolism
*Life-time ecstasy, amphetamine or cocaine use
*Intravenous drug abuse
*Participation in another study associated with exposure to ionizing radiation during the last 12 months
*Pregnancy
*Contra-indication for MRI
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Difference in binding ratio in the hypothalamus of the radioligand [123I]FP-CIT<br /><br>to serotonin transporters between subjects with pituitary insufficiency and<br /><br>clinical suspect for hypothalamic damage, subjects with hypopituitarism without<br /><br>suspicion of hypothalamic damage and healthy age- and gender matched controls.</p><br>
- Secondary Outcome Measures
Name Time Method <p>To define the optimal time-point of assessing central serotonin transporter<br /><br>binding with FP-CIT SPECT after injection of the radiotracer.</p><br>