Imaging serotonin transmission in the brain of depressed patients.

Not Applicable

• Conditions: Major depressive disorder, Adjustment disorder with depression

• Registration Number: JPRN-UMIN000012050
• Lead Sponsor: ational Institute of Radiological Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-10-18
• Study Completion: 2021-04-29
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Not provided

Exclusion Criteria

1) Subjects who lack the ability to provide informed consent 2) Subjects who take antidepressants except escitalopram, antipsychotics, mood stabilizers, or tandospirone. Subjects who took those medicines in 1 month. 3) Serious suicidal ideation or behavior 4) Co-morbid other psychiatric disorders including drug dependence 5) Existence of brain organic disease, including current or past history of cerebrovascular disease, Parkinson's disease, and other related disorders 6) Existence of serious medical illnesses 7) Pregnant women 8) lactating woman

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Regional endogenous serotonin release

Secondary Outcome Measures

Name	Time	Method
Relationship between regional endogenous serotonin release and density of 5-HT1A receptors, blood analysis, symptom, cognitive function and fMRI.