Effect of Vitamin D Supplementation as Adjuvant Therapy in Neonatal Jaundice in Combination With Phototherapy
- Registration Number
- NCT06650293
- Lead Sponsor
- Muhammad Aamir Latif
- Brief Summary
Neonatal jaundice frequently occur during initial week of life. Neonatal jaundice is one of the leading causes of hospital admission and readmission. Some studies have suggested that the healthy newborns with hyperbilirubinemia outside the physiological range have notably reduced serum vitamin D levels. This deficiency is inversely associated with neonatal hyperbilirubinemia, suggesting that low vitamin D levels could be a potential risk factor for jaundice among neonates.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- Both genders
- Admitted between 3-28 days of age.
- Indirect hyperbilirubinemia with TSB levels between 14-20 mg/dL
- Born via either cesarean or vaginal delivery
- Birth weight greater than 2500 grams
Exclusion Criteria
- Prior phototherapy treatment
- Preterm birth (gestational age below 37 weeks).
- SpO2 < 95% at the time of admission
- Severe respiratory distress or failure
- Neonatal sepsis
- Congenital anomalies
- Parents/guardians unwilling to let their neonates be part of this study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group-A Vitamin D Neonates receive phototherapy plus vitamin D
- Primary Outcome Measures
Name Time Method Total Serum bilirubin levels 5 days Total Serum bilirubin levels evaluated
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Pediatric Medicine Department University of Child Health Sciences, Children's Hospital Lahore
🇵🇰Lahore, Pakistan