Postoperative Anxiety and Depression Among Older Chinese Patients

Completed

• Conditions: Anxiety; Non-cardiac Surgery; Depression; Elderly Patients
• Interventions: Other: no intervention

• Registration Number: NCT06495840
• Lead Sponsor: Chinese PLA General Hospital

Brief Summary

A multicenter, prospective observational study to describe the socioeconomic characteristics and the occurrence of postoperative anxiety and depression in the Chinese old population.

Detailed Description

As China's population ages, the proportion of elderly people undergoing surgery increases. Perioperative anxiety and depression, particularly in elderly patients, is common and associated with multiple medical and social adversities. Previous studies have found a 31 percent risk of anxiety and 29 percent risk of depression in older perioperative patients. However, nationally representative epidemiological data for postoperative anxiety and depression, in particular elderly patients undergoing non-cardiac surgery, are unavailable in China. Therefore, providing nationwide epidemiological data on postoperative anxiety and depression in Chinese elderly patients provides a valuable opportunity for policy makers and health care professionals to optimize the management of geriatric mental health in China.

Study Timeline

• Study Start: 2020-04-01
• Primary Completion: 2022-04-30
• Study Completion: 2022-04-30
• Status Verified: 2024-07
• Study First Submitted: 2024-07-03
• Study First Submitted QC: 2024-07-03
• Last Update Submitted: 2024-07-03
• Study First Posted: 2024-07-11
• Last Update Posted: 2024-07-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 8525

Inclusion Criteria

1. elderly patients (age ≥ 65 years)
2. undergoing elective surgery with a planned overnight hospital stay following surgery
3. non-cardiac surgery, non-neurosurgical surgery

Exclusion Criteria

1. patients fully refused to participate in the study
2. patients with severe dementia, language disorder, severe hearing or visual impairment, coma, and end-stage status
3. patients whose surgeries were canceled
4. history of previous severe mental illness or long-term use of psychotropic medications
5. ASA grade ≥ 4
6. patients admitted to ICU immediately after surgery
7. patients who died within 7 days after surgery
8. patients who did not complete the scale assessment

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Elderly patients	no intervention	elderly patients undergo non-cardiac surgery (aged ≥ 65 years)

Primary Outcome Measures

Name	Time	Method
Depression	within 7 days after surgery	Primary outcomes were depression Patient Health Questionnaire 9 (PHQ-9).The PHQ-9 is a nine-item questionnaire for screening on the presence of depressive symptoms and monitoring depression severity. Items were scored on a four-point scale with total scores ranging from zero to twenty-seven. Scores were defined as: ≥5 mild, ≥10 moderate, and ≥15 severe level of depression. The recommended screening cutoff was ≥10, corresponding with at least a moderate level of depression. The higher the score, the worse the situation. The total score ranges from 0 to 27, and higher scores indicate more depressive symptoms.
Anxiety	within 7 days after surgery	The GAD-7 is a seven-item questionnaire for screening on the presence of generalized anxiety disorder and assessing its severity. Items were scored on a four-point scale with total scores ranging from zero to twenty-one. Scores were defined as: ≥5 mild, ≥10 moderate, and ≥15 severe anxiety. The recommended screening cutoff was ≥10, corresponding with at least a moderate level of anxiety. Higher scores mean more anxiety.

Trial Locations

Locations (1)

First Medical center of Chinese PLA General Hospital; 🇨🇳 Beijing, China