The Impact of Acute Oral Ketone Monoester Supplementation on Resting-state Brain Connectivity in Adults With Memory Complaints
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Cerebral blood flow
研究概览
简要总结
People who report subjective memory complaints have a greater risk of developing dementia. Memory issues may be an early warning sign of dysfunctional cerebral glucose metabolism and cerebral blood flow. Interventions that can restore cerebral metabolism and enhance cerebral blood flow may protect against conversion to dementia. Exogenous ketone supplements have been shown rapidly improves brain network function in young adults. Further, infusion studies demonstrate that ketone bodies enhance cerebral blood flow in cognitively normal adults. Whether acute ketone monoester supplementation can improve brain function in adults with subjective memory complaints is currently unknown.
This study will investigate the effects of a single ketone monoester dose on resting-state functional connectivity in the default mode network and resting cerebral blood flow in adults with subjective memory complaints.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 55 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •between the ages of 55 and 70
- •presence of subjective memory complaints as determined by the Prospective- Retrospective Memory Questionnaire
- •cognitively normal, e.g. score ≥26 on the Montreal Cognitive Assessment
排除标准
- •Presence of obesity (body mass index > 30 kg/m^2)
- •Presence of known cardiovascular disease
- •Presence of type 2 diabetes
- •History of cardiovascular events requiring hospitalization in the past 3 years (e.g., heart attack, stroke)
- •History of concussion(s) with persistent symptoms
- •Currently following a ketogenic diet and/or taking ketone body supplements
- •Diagnosis of any form of Alzheimer's disease or dementia
结局指标
主要结局
Cerebral blood flow
时间窗: 90 minutes
Sum of blood flow in the internal carotid and vertebral arteries via phase contrast MRI in ml/min.
Brain network connectivity
时间窗: 90 minutes
Functional connectivity of the default mode network (DMN) is measured via functional MRI. Changes in BOLD signal in each region are determined by independent component analysis and then functional connectivity is measured as a Pearson correlation (r) between the neural regions comprising the DMN and transformed into a z score.
次要结局
- Executive function(90 minutes)
- Attention and working memory(90 minutes)
- Working memory(90 minutes)
研究者
Jeremy Walsh
Assistant Professor
McMaster University