Evaluation of the Level of Oxidative Stress in Relation to the Type of Anesthesia in Parturients Whose Delivery Was Completed by Caesarean Section

Completed

• Conditions: Obstetric Anesthesia Problems
• Interventions: Other: Blood sampling

• Registration Number: NCT05973435
• Lead Sponsor: University Clinic Dr Dragisa Misovic-Dedinje

Brief Summary

The goal of this observational study is to assess the level of oxidative stress during cesarean section depending on the type of anesthesia applied and to determine the factors that can affect the level of oxidative stress.

The main questions it aims to answer are:

* is there any association between specific parameters of pregnancy, socio-demographic characteristics and laboratory analyses with an increased level of oxidative stress

* is there any association between type of anesthesia for ceasarean section with an increased level of oxidative stress

Blood sample would be taken from the participants in the study for these analyses on three occasions in 3 test tubes (before cesarean section, during cesarean section and after cesarean section).

Researchers will compare patients that received general anesthesia with patients under spinal regional anesthesia to see if there is any difference in level of oxidative stress measured by laboratory parameters.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-03-01
• Study First Submitted: 2023-07-25
• Study First Submitted QC: 2023-07-25
• Primary Completion: 2023-08-01
• Study First Posted: 2023-08-02
• Study Completion: 2023-10-01
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-28
• Last Update Posted: 2023-12-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

• ASA status I and II

Exclusion Criteria

• ASA status III and IV
• Emergency C section

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
General Anesthesia	Blood sampling	-
Spinal anesthesia	Blood sampling	-

Primary Outcome Measures

Name	Time	Method
Elevated level of oxidative stress	2 hours after C section	We will measure enzymes of oxidative stress before cesarean section, during cesarean section and after cesarean section.

Secondary Outcome Measures

Name	Time	Method
Level of cortisol	2 hours after C section	We will measure cortisol levels before cesarean section, during cesarean section and after cesarean section.
Lactate level	2 hours after C section	We will measure lactate levels before cesarean section, during cesarean section and after cesarean section.

Trial Locations

Locations (1)

Clinical Hospital Center "Dr. Dragisa Misovic, Dedinje"; 🇷🇸 Belgrade, Serbia