Assessment of maternal and placental oxidative & nitrosative stress and inflammatory markers in maternal obesity with and without preeclampsia
Recruiting
- Conditions
- Pregnant women age between 20-39 year. Volunteers are lean pregnant women with preeclampsia and without preeclampsia and obese pregnant women which will be sub-divided into two groups including uncomplicated maternal obesity and preeclamptic maternal obesity.Maternal obesity, oxidative stress, antioxidant, inflammation, placenta
- Registration Number
- TCTR20240318002
- Lead Sponsor
- Khon Kaen University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 80
Inclusion Criteria
1. Pregnant women were divided into four groups including preeclamptic obesity group, preeclamptic lean, uncomplicated obesity, and uncomplicated lean.
2. Singleton pregnancy
3. Normal vaginal delivery or cesarean delivery
4. No history of smoking, alcoholism, or exposure to teratogenic substances
5. No history of chronic diseases including chronic hypertension, diabetes mellitus, kidney, liver, immune and respiratory diseases, infections, and fetal anomalies
Exclusion Criteria
1)Newborn abnormalities
2)Low birth weight (defined as birth weight below 1000 g)
3)Obstetric complications during delivery and postpartum including uterine rupture retained placenta and postpartum hemorrhage
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Biomarker Placenta tissue, Maternal blood and umbilical cord blood, collected immediately after delivery, and biomarker analysis Biochemical assessment
- Secondary Outcome Measures
Name Time Method Anthropometric data Anthropometric data were collected from volunteers during the postpartum recovery period while they were admitted to the hospital ward. questionaire