Effect of oxygen during planned and emergency cesaraen section using spinal block on mother and new born baby
- Conditions
- Health Condition 1: O369- Maternal care for fetal problem, unspecifiedHealth Condition 2: null- Pregnant women
- Registration Number
- CTRI/2014/07/004759
- Lead Sponsor
- INDIAN COUNCIL OF MEDICAL RESEARCH
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 120
American Society of Anesthesiologists (ASA) grade I and II
Age >18 years
Single gestation
Parturient requiring cesarean delivery for -fetal tachycardia 161-180 bpm ,fetal bradycardia 100-109 bpm, variability (bpm) < 5 for 40â??90 minutes, decelerations Typical variable decelerations Single prolonged deceleration for up to 3 minutes and Accelerations with the absence of accelerations with otherwise normal trace
Patient refusal
Fetal causes-Prematurity, any known fetal abnormality
Any contraindication to regional anesthesia
Body mass index >45 kg/M2
Parturient requiring cesarean delivery with indication of immediate threat to life of women or fetus with no time for placement of spinal anesthesia.
Vasospastic arterial disease, previous arterial injury
Thrombocytosis
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Maternal and newborn plasma levels of Malondialdehyde (MDA) and total antioxidant statusTimepoint: Maternal plasma levels of Malondialdehyde (MDA) and total antioxidant status - arterial sample before spinal block to mother and then every 5 minutes till delivery of baby( means at 4-5 sample ) <br/ ><br>New born plasma levels of Malondialdehyde (MDA) and total antioxidant status - only one sample immediately after birth
- Secondary Outcome Measures
Name Time Method 1. Maternal blood gas analysis <br/ ><br>2. Fetal blood gas analysis <br/ ><br>3.Haemodynamics <br/ ><br>4.Maternal adverse effects- nausea ,vomiting etc <br/ ><br>5.Newborn resuscitaion and follow up <br/ ><br>Timepoint: 1. baseline and then every 5 minutes till delivery of baby <br/ ><br>2.only one sample at birth <br/ ><br>3.baseline and then every 5 minutes till delivery of baby <br/ ><br>4.During baseline till delivery of baby <br/ ><br>5.At birth and at 24 hours