Age-related Changes in Retinal Oxygen Extraction in Healthy Subjects
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Retinal oxygen extraction in different age groups
研究概览
简要总结
It has been found that several systemic and ocular diseases are associated with impaired retinal oxygen extraction. In the present study, retinal oxygen extraction will be measured in different age groups in order to identify age related changes in otherwise healthy subjects. In addition, the study will explore short-term changes in retinal metabolism induced by breathing pure oxygen. Measurements will be performed with dynamic vessel analyzer and laser speckle flowgraphy to evaluate retinal blood flow and retinal oxygen saturation, in order to calculate retinal oxygen extraction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women aged between 18 and 80 years
- •Signed informed consent
- •Normal ophthalmic findings, unless the investigator considers an abnormality to be clinically irrelevant for the purpose of the study
- •Normal findings in the medical history, unless the investigator considers an abnormality to be clinically irrelevant for the purpose of the study
- •Nonsmokers
排除标准
- •Abuse of alcoholic beverages or drugs
- •Participation in a clinical trial in the 3 weeks preceding the study
- •Symptoms of a clinically relevant illness in the 3 weeks before the first study day
- •Blood donation during the previous 3 weeks
- •Pregnant or breast-feeding women
研究组 & 干预措施
Arm 1
SAUERSTOFF medizinisch, Messer GmbH, Industriestrasse 5, 2352 Gumpoldskirchen, Austria Dose: min. 95.5%, breathing for max. 45 minutes
干预措施: Oxygen 100% Gas for Inhalation (Drug)
结局指标
主要结局
Retinal oxygen extraction in different age groups
时间窗: 15 minutes
次要结局
未报告次要终点
研究者
Doreen Schmidl
Assoc. Prof. Priv.-Doz. Dr.med.univ. PhD
Medical University of Vienna