Exercise Training and Insulin Sensitivity

Not Applicable

Withdrawn

• Conditions: Exercise; Obesity
• Interventions: Behavioral: exercise

• Registration Number: NCT05930834
• Lead Sponsor: University of Missouri-Columbia

Brief Summary

Regular exercise participation is known to reduce cardiometabolic disease risk but the impact that exercise training has on adipose tissue (AT) metabolism is poorly understood, particularly in humans. It is well established that exercise training improves whole-body glucose levels and increases insulin sensitivity, and this can occur within one or two weeks. These effects are usually due to adaptations in skeletal muscle, the tissue responsible for the majority of glucose disposal. However, many studies have now determined that exercise training also results in adaptations in AT that improve whole-body metabolic health by improving glucose uptake into the AT.

Skeletal muscle is thought to account for approximately 75-85% of glucose uptake , and this process is impaired in .individuals who are insulin-resistant state. It is postulated that the increased level of adiposity that accompanies severe obesity would result in higher dependency on AT for glucose uptake as the AT would be a bigger "sink". Thus the role of AT in inducing whole body insulin resistance is still unclear, particularly in individuals with obesity.

This study will examine the changes in AT glucose uptake before and after 4 weeks of exercise training in obese individuals and establish if there are sex differences.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-06-16
• Study First Submitted QC: 2023-07-03
• Study First Posted: 2023-07-05
• Study Start: 2024-07-01
• Status Verified: 2024-09
• Last Update Submitted: 2024-09-28
• Last Update Posted: 2024-10-01
• Primary Completion: 2025-10
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• non-smokers, weight stable (<4 kg) within the last 6 months will be recruited for this study.
• sedentary (not engaged in planned physical activities and performing less than a total of 2 h of physical activity per week during the last 6 months) men and women whose BMI is classified as obese (>30 kg/m2).

Exclusion Criteria

• cardiovascular disease, uncontrolled hypertension (no beta blockers), smokers, pregnant, have any recent changes in hormonal birth control, or on any medications known to impact metabolism.
• All participants will be regular sleepers with a duration of 7-9 hours/night.
• Subjects with orthopedic limitations will not be included.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Exercise	exercise	All subjects will undergo exercise training for 4 wks. 45-60 min of exercise, 4 sessions/wk supervised, 1 session unsupervised. intensity 60% of VO2 max

Primary Outcome Measures

Name	Time	Method
TB1CD4 protein expression	4 weeks	TB1CD4 protein expression
GLUT4 protein expression	4 weeks	protein expression

Secondary Outcome Measures

Name	Time	Method
percent body fat	4 weeks	Body fat will be measured using DEXA pre and post training

Trial Locations

Locations (1)

University of Misouri; 🇺🇸 Columbia, Missouri, United States