Is there an improvement of microcirculation regarding propofol vs. sevoflurane anaesthetic regimen during coronary artery bypass grafting?
Withdrawn
- Conditions
- coronary artery diseaseocclusive vascular disease10011082
- Registration Number
- NL-OMON30260
- Lead Sponsor
- Anesthesiologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
All patients undergoing elective CABG are included.
Exclusion Criteria
Exclusion criteria includes emergency surgery, recent myocardial infarction (less than 7 days old), concurrent valve surgery or redo CABG, chronic use of either corticosteroid medication or NSAIDS.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>5.1 Endpoints:<br /><br>5.1.1) Myocardial cell damage markers (Troponin I, CK, CK-MB) between both<br /><br>groups on T(0) to T(7).<br /><br>See protocol for Time intervals (T)</p><br>
- Secondary Outcome Measures
Name Time Method <p>5.1.2) Hemodynamic data, for example CO, CI, SV, SVR, PVR on T (0) to T(3).<br /><br>5.1.3) Microcirculation as measured by MFI on T(0) to T(5).<br /><br>5.1.4) Inflammatory markers (for example: leucocytes, CRP, TNF-a, IL-6,<br /><br>CD11b/CD18 cells).</p><br>