Comparing the Ketogenic Effect of Coconut Oil and Different Medium-chain Triglycerides
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Plasma Ketone Concentrations
研究概览
简要总结
The aim of this study is to compare the ketogenic effect of coconut oil and three MCT oils (60-40 , tricaprylin and triheptanoate) on the production of ketones in healthy adults. Each oil are evaluated individually or in combination over a 8h-period during which repeated blood sampling is performed.
详细描述
The study is composed of eight successive visits. Each visit consists of the consumption of one individual oil or a mixture of oils (20 g of coconut oil or 10 g of coconut oil + 10 g of MCT 60-40 or 20 g MCT 60-40 or 10 g coconut oil + 10 g tricaprylin or 20 g tricaprylin or 10 g coconut oil + 10 g triheptanoate or 20 g triheptanoate) and a 8h follow-up during which repeated blood samples are taken for laboratory analysis (plasma beta-hydroxybutyrate, acetoacetate, glucose, free fatty acids, triglycerides, total cholesterol, lactate and insulin).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adult over 18 y old.
排除标准
- •Fasting plasma glucose ≥7.0 mM (diabetics or pre-diabetics);
- •Clinically-significant gastro-intestinal disease/conditions.
- •Clinically-significant liver disease/dysfunction.
- •Clinically-significant cardiac disease/conditions.
- •Clinically-significant abnormal coagulation.
- •Taking a medication that could affect lipid and glucose metabolism
- •Hypertension
- •Pregnancy or breastfeeding
- •Exercising more than 3 times a week
结局指标
主要结局
Plasma Ketone Concentrations
时间窗: 8 hours
Total ketones = Plasma acetoacetate (µmol/L) + beta-hydroxybutyrate (µmol/L) measured over a 8 hour period (i.e. daily mean). Samples are taken every 30 minutes on a 8 hours period. The mean is reported here.
次要结局
- Plasma Acetoacetate/Beta-hydroxybutyrate Ratio(8 hours)