Comparing the Ketogenic Effect of Coconut Oil and Different MCTs

Not Applicable

Completed

• Conditions: Healthy Adults

• Registration Number: NCT02679222
• Lead Sponsor: Université de Sherbrooke

Brief Summary

The aim of this study is to compare the ketogenic effect of coconut oil and three MCT oils (60-40 , tricaprylin and triheptanoate) on the production of ketones in healthy adults. Each oil are evaluated individually or in combination over a 8h-period during which repeated blood sampling is performed.

Detailed Description

The study is composed of eight successive visits. Each visit consists of the consumption of one individual oil or a mixture of oils (20 g of coconut oil or 10 g of coconut oil + 10 g of MCT 60-40 or 20 g MCT 60-40 or 10 g coconut oil + 10 g tricaprylin or 20 g tricaprylin or 10 g coconut oil + 10 g triheptanoate or 20 g triheptanoate) and a 8h follow-up during which repeated blood samples are taken for laboratory analysis (plasma beta-hydroxybutyrate, acetoacetate, glucose, free fatty acids, triglycerides, total cholesterol, lactate and insulin).

Study Timeline

• Study Start: 2015-06
• Study First Submitted: 2016-02-01
• Study First Submitted QC: 2016-02-05
• Study First Posted: 2016-02-10
• Primary Completion: 2016-12
• Study Completion: 2017-03-01
• Results First Submitted: 2019-02-11
• Status Verified: 2020-03
• Results First Submitted QC: 2020-03-23
• Last Update Submitted: 2020-03-23
• Results First Posted: 2020-04-06
• Last Update Posted: 2020-04-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Healthy adult over 18 y old.

Exclusion Criteria

• Fasting plasma glucose ≥7.0 mM (diabetics or pre-diabetics);
• Smoking
• Clinically-significant gastro-intestinal disease/conditions.
• Clinically-significant liver disease/dysfunction.
• Clinically-significant cardiac disease/conditions.
• Clinically-significant abnormal coagulation.
• Taking a medication that could affect lipid and glucose metabolism
• Hypertension
• Pregnancy or breastfeeding
• Exercising more than 3 times a week

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Plasma Ketone Concentrations	8 hours	Total ketones = Plasma acetoacetate (µmol/L) + beta-hydroxybutyrate (µmol/L) measured over a 8 hour period (i.e. daily mean).; Samples are taken every 30 minutes on a 8 hours period. The mean is reported here.

Secondary Outcome Measures

Name	Time	Method
Plasma Acetoacetate/Beta-hydroxybutyrate Ratio	8 hours	Plasma ratio of acetoacetate (µmol/L)/ beta-hydroxybutyrate (µmol/L) measured over a 8 hour period (i.e area-under-the-curve over 8 hours).

Trial Locations

Locations (1)

Research Centre on Aging (CSSS-IUGS - CIUSSS de l'Estrie - CHUS); 🇨🇦 Sherbrooke, Quebec, Canada