NCT06472284
Active, not recruiting
Not Applicable
Train-of-four Monitoring Using the TetraGraph Neuromuscular Transmission Monitor to Evaluate Rocuronium Infusion Requirements During Major Neurosurgical and Surgical Procedures
Joseph D. Tobias1 site in 1 country50 target enrollmentSeptember 12, 2024
ConditionsSurgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Surgery
- Sponsor
- Joseph D. Tobias
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- EMG changes
- Status
- Active, not recruiting
- Last Updated
- 6 months ago
Overview
Brief Summary
This is a prospective, non-blinded study to evaluate rocuronium infusion requirements using the TetraGraph Neuromuscular Transmission Monitor during surgical procedures in patients less than 18 yrs. of age.
Investigators
Joseph D. Tobias
Chief, Dept. of Anesthesiology & Pain Medicine
Nationwide Children's Hospital
Eligibility Criteria
Inclusion Criteria
- •Patients less than 18 years of age
- •American Society of Anesthesiologists classification (ASA) 1-4
- •Patients undergoing a surgical procedure with general anesthesia and requiring the continuous administration of rocuroniuim
Exclusion Criteria
- •Patients less than 28 days old
- •Patients with history of a progressive or degenerative peripheral neurologic or neuropathic disorder
- •Patients undergoing a surgical procedure in which neuromuscular blockade is not required
- •Edematous patients
Outcomes
Primary Outcomes
EMG changes
Time Frame: During the surgery (2-8 hrs.)
Changes in the amplitude of the evoked response of the muscles
Maximum dose of rocuronium
Time Frame: During the surgery (2-8 hrs.)
The maximum dose of rocuronium administered by a continuous infusion to maintain one twitch of the train of four (TOF)
Study Sites (1)
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