A Contribution to the Analysis of the Phenotypic Heterogeneity in Crack/Cocaine Addiction : a Case Control Study

Not Applicable

• Conditions: Dependence, Cocaine

• Registration Number: NCT01025219
• Lead Sponsor: University Hospital Center of Martinique

Brief Summary

The purpose of this study is to assess the phenotypic candidates symptoms, in patients with crack/cocaine addiction, in terms of clinical comorbidities, dimensions of personality, and neuropsychological evaluations apt to be associated with genetic and genotypic characterisations, notably on the polymorphisms of the genes coding or regulating dopaminergic, norepinephrine and serotoninergic systems.

Detailed Description

Genetic studies show an association between drug addiction and the dopaminergic system and its modulators. Nonetheless, results are contradictory, partially due to the heterogeneity of the phenotype addiction. Placed on the trafficking route of cocaine, and homogeneously populated, Martinique is of particular interest for the study of the vulnerability of the crack/cocaine addiction. In a precedent study, supported by a grant MILDT / INSERM 2000, on 155 men dependent to crack/cocaine and characterised with three clinical dimensions -sensation seeking, impulsivity and childhood ADHD- we found an association between each dimension and polymorphisms of DRD2 and DRD4 genes.

Study Timeline

• Study Start: 2009-12
• Study First Submitted: 2009-12-01
• Study First Submitted QC: 2009-12-02
• Study First Posted: 2009-12-03
• Status Verified: 2011-03
• Last Update Submitted: 2011-03-21
• Last Update Posted: 2011-03-22
• Primary Completion: 2012-12
• Study Completion: 2012-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 600

Inclusion Criteria

• Diagnosis of cocaine abuse/dependence according to DSM-IV-TR criteria
• Come from French West Indies (3 grandparents are African-Caribbean)
• Sign a written informed consent

Exclusion Criteria

• Minor
• Men with no cocaine abuse/dependence according to DSM-IV-TR criteria

For the control:

Inclusion Criteria:

• Platelets donor
• No substance abuse/dependence according to DSM-IV-TR criteria
• Come from French West Indies (3 grandparents are African-Caribbean)
• Sign a written informed consent

Exclusion Criteria:

• Minor
• Men refusing a genetic study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
The specific measure that will be related to core objectives of the study is to constitute a sample collection from saliva.	The saliva will be collect at the end of the first visit

Trial Locations

Locations (1)

Service de psychiatrie et addictologie - CHU de Fort-de-France; 🇫🇷 Fort-de-France, Martinique, France