Effects of Preoperative Immunonutrition in Patients Undergoing Pancreaticoduodenectomy
Phase 4
Completed
- Conditions
- Pancreatic CancerBile Duct Cancer
- Registration Number
- NCT01256034
- Lead Sponsor
- Chiba University
- Brief Summary
The purpose of this study is to determine whether preoperative immunonutrition is effective on infectious complication and Th1/Th2 differentiation in patients with pancreaticoduodenectomy.
- Detailed Description
The investigators reported that preoperative immunonutrition improve the incidence of postoperative infectious complication in patients after pancreaticoduodenectomy, and modulation of Th1/Th2 differentiation may play important roles in this effect.
Object of this study is to investigate the effects preoperative immunonutrition on incidence of postoperative infectious complication, and Th1/Th2 balance after pancreaticoduodenectomy.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- patients underwent pancreaticoduodenectomy
Exclusion Criteria
- age younger than 18 years
- ongoing infection
- gastrointestinal obstruction
- respiratory dysfunction
- cardiac dysfunction
- hepatic dysfunction
- renal failure
- history of recent immunosuppressive or immunological diseases
- preoperative evidence of widespread metastatic disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Postoperative Infectious Complication 30 days
- Secondary Outcome Measures
Name Time Method Plasma IL-6, CRP, Th1/Th2 Balance 14 days
Trial Locations
- Locations (1)
Chiba University
🇯🇵Chiba, Japan
Chiba University🇯🇵Chiba, Japan