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Effects of Preoperative Immunonutrition in Patients Undergoing Hepatectomy

Phase 4
Completed
Conditions
Bile Duct Cancer
Registration Number
NCT01256047
Lead Sponsor
Chiba University
Brief Summary

The purpose of this study is to determine whether preoperative immunonutrition is effective on infectious complication and Th1/Th2 differentiation in patients with major hepatectomy.

Detailed Description

The investigators reported that preoperative immunonutrition improve the incidence of postoperative infectious complication in patients after hepatectomy, and modulation of Th1/Th2 differentiation may play important roles in this effect.

Object of this study is to investigate the effects of preoperative immunonutrition on incidence of postoperative infectious complication, and Th1/Th2 balance after hepatectomy.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
40
Inclusion Criteria
  • hepatectomy
Exclusion Criteria
  • age younger than 18 years
  • ongoing infection
  • gastrointestinal obstruction
  • respiratory dysfunction
  • cardiac dysfunction
  • hepatic dysfunction
  • renal failure
  • history of recent immunosuppressive or immunological disease
  • preoperative evidence of widespread metastatic disease

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Primary Outcome Measures
NameTimeMethod
postoperative infectious complication30 days
Secondary Outcome Measures
NameTimeMethod
plasma IL-6, CRP, Th1/Th2 balance14 days

Trial Locations

Locations (1)

Chiba University

🇯🇵

Chiba, Japan

Chiba University
🇯🇵Chiba, Japan

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