Effects of Immunonutrition on Surgical Site Infection and Th1/Th2/Th17 Differentiation in Patients Undergoing Pancreaticoduodenectomy
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- surgical site infection after surgery
研究概览
简要总结
The purpose of this study is to determine whether immunonutrition is effective on surgical site infection and Th1/Th2/Th17 differentiation in patients undergoing pancreaticoduodenectomy
详细描述
Perioperative immunonutrition is reported to improve the incidence of postoperative infectious complication in patients with gastrointestinal surgery. It has also been recognized that Th1/Th2 balance shifts toward Th2 by surgical stress. On the other hand, the change of Th17 status after surgery has not been established. Furthermore, The change of Th1/Th2 balance and Th17 status with immunonutrition on pancreaticoduodenectomy have not been reported yet.
Objective of this study is to investigate the effects of perioperative immunonutrition on incidence of postoperative infectious complication, Th1/Th2 balance and Th17 status after pancreaticoduodenectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients underwent pancreaticoduodenectomy
排除标准
- •age younger than 18 years or older than 75 years
- •preoperative chemotherapy or radiation
- •ongoing infection
- •diabetes mellitus
- •gastrointestinal obstruction
- •respiratory dysfunction
- •cardiac dysfunction
- •hepatic dysfunction
- •renal failure
- •history of recent immunosuppressive or immunological diseases
- •preoperative evidence of widespread metastatic disease
结局指标
主要结局
surgical site infection after surgery
时间窗: 30days
次要结局
- plasma IL-6, CRP, Th1/Th2 balance, Th17 status(14 days)