To decrease the response of intubation using either esmolol or enalaprilat in controlled hypertensive patients

Not Applicable

• Conditions: Health Condition 1: null- Patients with controlled hypertension, scheduled for surgery under general anaesthesia requiring tracheal intubation will be recruited

• Registration Number: CTRI/2017/08/009230
• Lead Sponsor: DRPGMCKangra at Tanda

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

The patients will be surgical candidates, either gender,aged 40-60 yrs weighing 40-70 kgs and controlled hypertensive patient,belonging to ASA II, scheduled for surgery under general anaesthesia requiring tracheal intubation

Exclusion Criteria

1.Patients having recent myocardial infarction (less than 6 months duration), partial and complete heart block, bradycardia.

2.Patients having chronic obstructive lung disease, asthma

3.Patients having marked systolic and diastolic dysfunction based upon electrocardiographic or echocardiographic studies as indicated.

4.Severe renal or hepatic dysfunction

5.Morbidly obese patients , pregnant females

6.Bilateral renal artery stenosis

7.Hypersensitivity to ACE inhibitors

8.Patients with anticipated difficult intubation

9.Diabetic patients

10.Patients already on tablet enalaprilat or β blocker drugs in the preoperative period.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) will be recorded baseline, after study drug administration, after induction and 1, 3, 5, 10, and 15 min after orotracheal intubation.Timepoint: Time Points <br/ ><br>Induction <br/ ><br>Intubation <br/ ><br>1 min after intubation <br/ ><br>3 min after intubation <br/ ><br>5 min after intubation <br/ ><br>10 min after intubation <br/ ><br>15 min after intubation

Secondary Outcome Measures

Name	Time	Method
Rate Pressure Product on induction, intubation and incidence of adverse effetcs if anyTimepoint: induction, <br/ ><br>intubation <br/ ><br> 1 min after intubation <br/ ><br>3 minutes after intubation <br/ ><br>5 min after intubation <br/ ><br>10 min after intubation <br/ ><br>15 min after intubation <br/ ><br>2) incidence of side effetcs if any over a aperiod of 24 h