effect of ketamine on controlling pain after total knee arthroplasty

Phase 2

Conditions: Osteoarthritis of knee.
Unilateral primary osteoarthritis of knee
M17.1

Registration Number: IRCT20220315054298N1

Lead Sponsor: Tehran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 60

Inclusion Criteria

Between 18 and 85 years old
undergoing unilateral, primary total knee arthroplasty TKA for degenerative end-stage osteoarthritis(OA) of the knee (score of >2 on Kellgren-Lawrence scale).

Exclusion Criteria

patients who refuse to participate,
classified as ASA IV or V by the American Society of Anesthesiologists,
body mass index greater than 40 kg/m2,
rheumatoid arthritis,
contraindication or allergy to opioid pain medications
allergy to amide or sulpha anesthetics,
unable to understand the visual analog scale (VAS) ,
any preoperative ketamine or chronic narcotic usage (>10mg systemic morphine equivalents daily ) as it causes opioids tolerance ,
those who are discharged before the first 24 hours postoperatively,
previous history of knee arthroplasty,
prior surgery on the ipsilateral knee within 6 months,
simultaneous bilateral arthroplasty,
the patients receiving general anesthesia or a nerve block
patients with an ejection fraction of less than 30%,
creatinine clearance of less than 30mL/min,
chronic liver disease,
any neurologic or psychiatric disorder (including bipolar,post-traumatic stress disorder, schizophrenia),
chronic alcohol abuse

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain. Timepoint: 2 hour , 6hour , 12 hour ,24 hour ,10 days ,42 days post operative. Method of measurement: Visual Analogue Scale.

Secondary Outcome Measures

Name	Time	Method
Maximum post op knee flexion. Timepoint: at discharge ,post op day 10 , post op day 42. Method of measurement: orthopedic ruler.;Hospital stay duration. Timepoint: from the end of operation to discharge time. Method of measurement: time-hour.;Time of first morphine request. Timepoint: from the end of operation to first time of morphine request. Method of measurement: time-hour.;Total morphine(analgesics) consumption. Timepoint: at the time of discharge. Method of measurement: mg/kg....patient document.