ow-frequency repetitive transcranial magnetic stimulation augmented the beneficial effects of task-specific training on paretic hand function following subacute stroke
- Conditions
- o adverse events.Brain stimulation,Neural plasticity,Task-specific training,Dexterity
- Registration Number
- TCTR20161230002
- Lead Sponsor
- Faculty of Physical Therapy, Mahidol University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 16
The inclusion criteria were as follows: (1) onset of subcortical ischemic or hemorrhage stroke within 1-6 months as verified by medical records or CT/MRI findings, (2) age of 20-79 years, (3) right handedness as evaluated using the Edinburgh Handedness Inventory, (4) mild to moderate impairment of an upper extremity based on the Fugl-Meyer Assessment (FMA), (5) able to understand and follow simple commands as evaluated by the 2002 Thai version of the Mini Mental State Examination (MMSE), (6) able to perform mass extension of finger (score on the hand section of the FMA of at least 1), (7) able to sit independently for more than one hour, (8) normal or corrected hearing and vision, and (9) no motor aphasia, sensory aphasia, or global aphasia.
(1) contraindication of rTMS, such as seizures or an intracranial metallic implant, as confirmed by a TMS screening questionnaire, (2) other neurological and musculoskeletal problems affecting the arm, hand, or trunk that might interfere with task achievement, such as pain in at least 3 of 5 joints (of the upper extremities) based on the joint pain domain of the FMA (FMA pain score of zero), (3) lesions in other brain areas such as the brainstem or cerebellum or brain damage that was bilateral or of non-vascular etiology such as traumatic brain injury, and (4) receipt of task-specific training during the study period.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method corticospinal excitability of the non-lesioned hemisphere baseline, after the LF-TMS session, and immediately, 1 week, and 2 weeks after motor training Transcranial Magnetic Stimulation
- Secondary Outcome Measures
Name Time Method by total movement time on the Wolf Motor Function Test of 2 hands baseline, after the LF-TMS session, and immediately, 1 week, and 2 weeks after motor training Clinical measurement