Does brain stimulation improve post-stroke depression?

Not Applicable

Completed

• Conditions: Stroke; Depression; Stroke - Ischaemic; Stroke - Haemorrhagic; Mental Health - Depression

• Registration Number: ACTRN12619001303134
• Lead Sponsor: niversity of South Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-09-23
• Study Completion: 2020-01-24
• Last Update Posted: 2 November 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 11

Inclusion Criteria

Stroke (ischemic or hemorrhagic)
Mild to severe depression as measured by the PHQ-9 score (5-27)
No contraindications for rTMS
no change in antidepressant medication for 6 months prior to treatment

Exclusion Criteria

Unsafe for TMS

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in Beck Depression Inventory score[Baseline, Immediately Post-treatment (primary timepoint) and 1 month follow-up];Change in PHQ-9 score[Baseline, Immediately Post-treatment (primary timepoint) and 1 month follow-up]

Secondary Outcome Measures

Name	Time	Method
Change in stroke specific self efficacy score (item 1-13)[Baseline, Immediately Post-treatment and 1 month follow-up];Adverse events assessed immediately post treatment using a rTMS specific adverse events form that has been adapted from Brunoni et al. 2011 ( International Journal of Neuropsychopharmacology) And Gillick et al 2015 (Archives of Physical Medicine and Rehabilitation). Examples of possible adverse events can be found in the stated refereces and may include headache, scalp pain, fatigue<br>[Immediately Post treatment];Resting state EEG functional connectivity[Baseline, Immediately Post treatment];Resting state EEG power[Baseline, Immediately post treatment]