A Randomised Controlled Study looking at Cardiovascular Effects of Closure of Arteriovenous Fistulae after Kidney Transplantatio
Not Applicable
Completed
- Conditions
- kidney transplant recipientsRenal and Urogenital - Other renal and urogenital disordersCardiovascular - Other cardiovascular diseases
- Registration Number
- ACTRN12613001302741
- Lead Sponsor
- Renal Unit, Royal Adelaide Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 64
Inclusion Criteria
Aged 18-80, treated at the Royal Adelaide Hospital Renal Unit following successful Renal Transplantation > 12 months, who continue to have a functioning AV Fistula. Renal functions should be stable (eGFR> 60 ml/min) for at least 5 months prior to enrolment or one deemed at low risk for transplant failure by treating physician.
Exclusion Criteria
Solid organ or haematological malignancy in last 5 years
Presence of contraindications to MRI
Pregnancy
Physician concern regarding closure of AV fistula
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome will be assessed by looking at improvement in the left ventricular mass. A difference of more than 9.5 gram after 6 months has shown to be significant in previous studies. The LV mass will be measured by cardiac MR scan. [6 months]
- Secondary Outcome Measures
Name Time Method LV end diastolic volumes measured by cardiac MR scan[6 months];LV end systolic volume measured by cardiac MR scan[6 months];Left atrial enlargement measured by cardiac MR scan[6 months];right atrial enlargement measured by cardiac MR scan[6 months];pulmonary flow measured by cardiac MR scan[6 months];LV ejection fraction measured by cardiac MR scan[6 months];Cardiac output and cardiac index measured by cardiac MR scan[6 months];Ipsilateral brachial artery flow[6 months];N terminal Pro brain natriuretic peptide [6 months]