How effective is Acetazolamide in preventing elevated cerebrospinal fluid pressure and therefore paralysis of the leg in patients during thoracic-abdominal aortic aneurysm repair surgery.
- Conditions
- Elevated cerebrospinal fluid pressure in patients undergoing thoracic-abdominal aortic repairTherapeutic area: Diseases [C] - Cardiovascular Diseases [C14]
- Registration Number
- EUCTR2013-001447-31-GB
- Lead Sponsor
- iverpool Heart and Chest Hospital NHS Foundation Trust
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 60
- Elective patients who have given consent and are 18+ years
- Patients able to comply with the pre-operative course of acetazolamide treatment (treatment group) and who have had a blood sample collected at least three days prior to surgery
Are the trial subjects under 18? no
Number of subjects for this age range: 0
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 40
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 20
- Non-elective patients, who were not able to participate in pre-operative acetazolamide treatment and blood sample tests three days prior to surgery
- Patients without consent
- Patients under the age of 18
- Patients unable to independently comprehend and complete the consent form
- Patients unable to independently comply to the pre-operative course of acetazolamide treatment
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method