Subclinical Hypothyrodism and Ovarian Reserve

• Conditions: Fertility Disorders

• Registration Number: NCT05409729
• Lead Sponsor: Assiut University

Brief Summary

This study aimed to evaluate the potential association of subclinical hypothyrodism and ovarian reserve in reproductive age in age groups more than 35 and age groups less than 35 using retrospective study included women with subclinical hypothyrodism and controls .Evaluation of potential association of antithyroid antibodies positivity on ovarian reserve

Primary outcome:

Measure the association of SCH with ovarian reserve markers (basal FSH ,LH/basal AFC /AMH)

Detailed Description

Thyroid dysfunction is one of the commonest disorders in women of reproductive age .there is association between subclinical hypothyrodism and infertility and ovarian reserve .It's known that subclinical hypothyrodism can be associated with reduced ovarian reserve in women more than 35 years old .Aclear association between subclinical hypothyrodism and ovarian reserve not established in reproductive age in women less than 35 .This retrospective study investigate serum thyroid hormone /Antithyroid hormone ,ovarian reserve markers (basal FSH,AMH,Antral follicle count on day 2-4/prolactin level .

Study Timeline

• Study Start: 2016-01-01
• Primary Completion: 2020-01-01
• Status Verified: 2022-06
• Study First Submitted: 2022-06-04
• Study First Submitted QC: 2022-06-04
• Last Update Submitted: 2022-06-04
• Study First Posted: 2022-06-08
• Last Update Posted: 2022-06-08
• Study Completion: 2023-08-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 300

Inclusion Criteria

• All reproductive age groups included women less than 35 and women more than 35

Exclusion Criteria

• Previous ovarian surgery Women with long term thyroid hormone replacement Endometriosis History of radiotheraby

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Measure the association of SCH with ovarian reserve markers (basal FSH ,LH/basal AFC /AMH)	48 months	This study aimed to evaluate the potential association of subclinical hypothyrodism and ovarian reserve in reproductive age in age groups more than 35 and age groups less than 35 using retrospective study included women with subclinical hypothyrodism and controls .Evaluation of potential association of antithyroid antibodies positivity on ovarian reserve

Trial Locations

Locations (1)

Assiut Medical School; 🇪🇬 Assiut, Egypt