Speech, Linguistic and Acoustic Markers in Parkinson's Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 58
- 试验地点
- 1
- 主要终点
- Mild Cognitive Impairment
研究概览
简要总结
The Investigators aim to identify speech and language markers that provide information on cognitive function and predict cognitive decline in Parkinson's disease. The Investigators will administer speech tasks and cognitive assessments to participants with Parkinson's disease and healthy controls. The Investigators will also explore the associations between genetic factors and speech and cognitive status in Parkinson's disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Parkinson's Disease (or healthy control)
- •Disease duration ≥ 2 years
- •Mild cognitive impairment or normal cognition
排除标准
- •Diagnosis of dementia (MoCA <21)
- •Adults unable to consent
- •Age < 18
- •Pregnant women
- •Prisoners
- •Non-English speakers
- •Any neurological disorder other than PD
- •Deep brain stimulator placement
- •Severe, unstable psychiatric disorder
- •Unintelligible speech due to effects of PD
- •Visual acuity or color vision impairment that would interfere with cognitive testing
- •Other voice, speech or swallowing disorders or history of surgery involving palate/nasopharynx/larynx/vocal cords
结局指标
主要结局
Mild Cognitive Impairment
时间窗: baseline
Mild cognitive impairment classified by Movement Disorders Society Task Force Level II Critieria
Mean Fundamental Frequency
时间窗: baseline
These acoustic measures during spontaneous speech (picture description) were calculated using Praat
次要结局
未报告次要终点
研究者
Kara Smith
Assistant Professor of Neurology
University of Massachusetts, Worcester