Speech, Linguistic and Acoustic Markers in Parkinson's Disease

Completed

• Conditions: Speech; Cognitive Impairment, Mild; Parkinson Disease

• Registration Number: NCT04273672
• Lead Sponsor: University of Massachusetts, Worcester

Brief Summary

The Investigators aim to identify speech and language markers that provide information on cognitive function and predict cognitive decline in Parkinson's disease. The Investigators will administer speech tasks and cognitive assessments to participants with Parkinson's disease and healthy controls. The Investigators will also explore the associations between genetic factors and speech and cognitive status in Parkinson's disease.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-13
• Study First Submitted: 2020-02-12
• Study First Submitted QC: 2020-02-13
• Study First Posted: 2020-02-18
• Primary Completion: 2023-09-01
• Study Completion: 2025-02-28
• Results First Submitted: 2025-04-17
• Status Verified: 2025-06
• Results First Submitted QC: 2025-06-07
• Last Update Submitted: 2025-06-07
• Results First Posted: 2025-06-10
• Last Update Posted: 2025-06-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 58

Inclusion Criteria

• Parkinson's Disease (or healthy control)
• Disease duration ≥ 2 years
• Mild cognitive impairment or normal cognition

Exclusion Criteria

• Diagnosis of dementia (MoCA <21)
• Adults unable to consent
• Age < 18
• Pregnant women
• Prisoners
• Non-English speakers
• Any neurological disorder other than PD
• Deep brain stimulator placement
• Severe, unstable psychiatric disorder
• Unintelligible speech due to effects of PD
• Visual acuity or color vision impairment that would interfere with cognitive testing
• Other voice, speech or swallowing disorders or history of surgery involving palate/nasopharynx/larynx/vocal cords

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mild Cognitive Impairment	baseline	Mild cognitive impairment classified by Movement Disorders Society Task Force Level II Critieria
Mean Fundamental Frequency	baseline	These acoustic measures during spontaneous speech (picture description) were calculated using Praat

Trial Locations

Locations (1)

UMass Medical School/UMass Memorial Medical Center; 🇺🇸 Worcester, Massachusetts, United States