Speech, Linguistic and Acoustic Markers in Parkinson's Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Parkinson Disease
- Sponsor
- University of Massachusetts, Worcester
- Enrollment
- 58
- Locations
- 1
- Primary Endpoint
- Mild Cognitive Impairment
- Status
- Completed
- Last Updated
- 10 months ago
Overview
Brief Summary
The Investigators aim to identify speech and language markers that provide information on cognitive function and predict cognitive decline in Parkinson's disease. The Investigators will administer speech tasks and cognitive assessments to participants with Parkinson's disease and healthy controls. The Investigators will also explore the associations between genetic factors and speech and cognitive status in Parkinson's disease.
Investigators
Kara Smith
Assistant Professor of Neurology
University of Massachusetts, Worcester
Eligibility Criteria
Inclusion Criteria
- •Parkinson's Disease (or healthy control)
- •Disease duration ≥ 2 years
- •Mild cognitive impairment or normal cognition
Exclusion Criteria
- •Diagnosis of dementia (MoCA \<21)
- •Adults unable to consent
- •Age \< 18
- •Pregnant women
- •Prisoners
- •Non-English speakers
- •Any neurological disorder other than PD
- •Deep brain stimulator placement
- •Severe, unstable psychiatric disorder
- •Unintelligible speech due to effects of PD
Outcomes
Primary Outcomes
Mild Cognitive Impairment
Time Frame: baseline
Mild cognitive impairment classified by Movement Disorders Society Task Force Level II Critieria
Mean Fundamental Frequency
Time Frame: baseline
These acoustic measures during spontaneous speech (picture description) were calculated using Praat