Endocan Blood Level in Pulmonary Circulation

• Conditions: Cardiopulmonary Bypass; Lung; Cardiac Surgery

• Registration Number: NCT04616820
• Lead Sponsor: Centre Hospitalier Universitaire de Besancon

Brief Summary

Endocan is a proteoglycan produced by the vascular endothelium. Animal studies suggested that the synthesis mainly happen in the pulmonary circulation, but this hypothesis has never been confirmed in humans.

Detailed Description

The investigators will measure endocan levels in both pulmonary and systemic venous blood in patients undergoing on pump cardiac surgery.

The main objective is to quantify the difference of endocan blood level between the pulmonary and the systemic circulation.

Study Timeline

• Study First Submitted: 2020-10-30
• Status Verified: 2020-11
• Study First Submitted QC: 2020-11-04
• Study First Posted: 2020-11-05
• Last Update Submitted: 2021-02-04
• Last Update Posted: 2021-02-05
• Study Start: 2021-03
• Primary Completion: 2021-06
• Study Completion: 2021-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Planned on pump coronary artery bypass surgery
• Non opposition

Exclusion Criteria

• Age < 18 years old
• Emergent surgery
• Valvular replacement surgery
• Combined cardiac surgery
• Patients with inflammatory, infectious or evolutive neoplastic pulmonary disease
• Patients with valvular problems, in particular aortic insufficiency
• Patients who refuse to participate
• Legal inability or disability
• Patients who will probably not cooperate for the study
• Pregnancy and/or breast feeding
• Patients not in the Social security system
• Patients in the exclusion period of another study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quantify the difference of Endocan blood levels between pulmonary and systemic circulation at the end of cardiopulmonary bypass	At the end of cardiopulmonary bypass	Blood samples will be collected at the same time in both pulmonary and systemic circulation at the end of cardiopulmonary bypass to measure Endocan blood level. The primary outcome will be the absolute difference between the Endocan blod level in the pulmonary circulation and in the systemic circulation.

Secondary Outcome Measures

Name	Time	Method
Kinetic of Endocan blood level in the systemic circulation during on pump cardiac surgery	Prior to the start of cardiopulmonary bypass, at the beginning and at the end of cardiopulmonary bypass, and at the end of surgery	Blood samples will be collected in the systemic circulation prior to the start of cardiopulmonary bypass, at the beginning of the cardiopulmonary bypass and at the end of cardiopulmonary bypass, and at the end of the surgery