Movement Diagnostic System: Quantitative diagnosis of patients with Parkinson's Disease, essential tremor and dystonia, a closed-loop approach with fMRI

Recruiting

Conditions: involuntary movements
movement disorders
10028037

Registration Number: NL-OMON36806

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 100

Inclusion Criteria

• 18 years or older
• Right-handed according to the Edinburgh Handedness Inventory
• Willingness to stop medication intake for eight hours prior to investigations
And either:
• Essential tremor according to criteria defined by the Tremor Investigation Group, moderate to severe tremor (Tremor Rating Scale Part A 2 UE>2) ;
Hereditary ET (positive family history: at least one affected relative in immediate family;
Onset in patient and family member before age 65);
Positive effect of propranolol on tremor.
• Parkinson*s disease according to the UK Brain Bank criteria for Parkinson*s disease;
No major fluctuations in symptoms due to medication;
No severe dyskinesia.
• Limb dystonia with at least 35 points on the motoric part of the Burke-Fahn-Marsden Dystonia Rating Scale
• Healthy age and sex-matched controls

Exclusion Criteria

• MR-incompatible implanted metal bodies, including stereotactic implant for Deep Brain Stimulation and pacemakers.
• Other contraindications for MR (Claustrophobia, obesity, etc.)
• Use of medicines/drugs that could influence the performance during the tasks (such as anti-epileptic drugs, neurodepressants, etc.)
• Pregnancy or suspected pregnancy
• Incapability to give informed consent
• Other neurological disorder than ET/PD-T/dystonia including dementia
• Abnormalities of the hand/wrist or prior surgery of the hand/wrist

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p> Differentiation between ET, PD-T and DYS based on brain activations<br /><br>specifically related to involuntary movements. With external measures and<br /><br>perturbation of the closed sensorimotor loop during fMRI we expect to find<br /><br>involvement of the olivocerbellar networks in ET, the striatum in PD-T and a<br /><br>widespread involvement of basal ganglia, thalamus, and cerebral cortex in<br /><br>dystonia. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Observation and identification of the brain regions involved in (the early<br /><br>stages) of movement disorders with overlapping symptoms will contribute to the<br /><br>knowledge on the occurrences and causes of these diseases on a more fundamental<br /><br>level. </p><br>