Movement Diagnostic System: Quantitative diagnosis of patients with Parkinson's Disease, essential tremor and dystonia, a closed-loop approach with fMRI.
- Conditions
- movement disordersdiagnosis closed-loop approachfMRI
- Registration Number
- NL-OMON28203
- Lead Sponsor
- Academic Medical Center University of AmsterdamPO-box: 226601100 DD AmsterdamTel: +31 (0)20.5669111
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
1. 18 years or older;
2. Right-handed according to the Edinburgh Handedness Inventory;
Exclusion Criteria
1. MR-incompatible implanted metal bodies, including stereotactic implant for Deep Brain Stimulation and pacemakers;
2. Other contraindications for MR (Claustrophobia, obesity, etc.);
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Differentiation between ET, PD-T and DYS based on brain activations specifically related to involuntary movements. With external measures and perturbation of the closed sensorimotor loop during fMRI we expect to find involvement of the olivocerbellar networks in ET, the striatum in PD-T and a widespread involvement of basal ganglia, thalamus, and cerebral cortex in dystonia.
- Secondary Outcome Measures
Name Time Method Observation and identification of the brain regions involved in (the early stages) of movement disorders with overlapping symptoms will contribute to the knowledge on the occurrences and causes of these diseases on a more fundamental level.