Technology-based Analysis of Movement Disorders

Not Applicable

• Conditions: Movement Disorders
• Interventions: Device: kinematic analysis

• Registration Number: NCT04591132
• Lead Sponsor: University College, London

Brief Summary

Objectives: To generate pilot data to investigate the feasibility and the potential use in clinical practice of technology based objective measures of motor performances in patients affected by different movement disorders. To correlate kinematics findings with demographic and clinical details. Trial design and methods: Participants enrolled in prof. Bhatia's movement disorders clinic, will be classifies according to the main movement disorder, specifically, tremor, parkinsonism, dystonia, chorea, ataxia. In the study visit (one day only), they will undergo a clinical evaluation using the appropriate clinical scales (respectively, Fahn-Tolosa-Marin tremor rating scale, MDS-UPDRS Part III, Toronto Western Spasmodic Torticollis Rating Scale 2, Unified Hungtington Disease Rating scale and Scale for the Assessment and Rating of Ataxia) and a kinematic evaluation, using wearables and an infra-red and LED markers system. Then the protocol is concluded and they will continue the routine clinical follow-up

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-05-29
• Status Verified: 2020-10
• Study First Submitted QC: 2020-10-15
• Last Update Submitted: 2020-10-15
• Study First Posted: 2020-10-19
• Last Update Posted: 2020-10-19
• Study Start: 2020-11-01
• Primary Completion: 2022-10-01
• Study Completion: 2023-10-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• clinical diagnosis of parkinsonism and/or dystonia and/or tremor due to:

  1. idiopatic parkinson's disease
  2. atypical parkinsonism
  3. sporadic or inherited/genetic dystonia
  4. young-onset Parkinson's disease
  5. Ataxia syndrome
  6. Choereic syndrome
  7. Essential tremor
  8. Dystonic tremor

• 18 to 80 years of age

• Willing and able to provide informed consent

• able to walk unassisted

Exclusion Criteria

• Change in pharmacological therapy in the last 3 months.
• Participated in a clinical drug trial up to 3 months before inclusion into the present study
• Orthopaedical comorbidities affecting gait or posture.
• Cognitive deficit

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
kinematic analysis	kinematic analysis	each patient with a diagnosis of parkinsonism, ataxia, chorea, dystonia or tremor will be asked to perform some motor tasks routinely used in clinical evaluation wearing inertial sensors.

Primary Outcome Measures

Name	Time	Method
gait metrics	up to 6 weeks after enrolment	gait cycles measures (step length, phase duration, number of steps) practice of technology based objective measures of motor performances in patients affected by different movement disorders, to objectively evaluate the disease burden, the efficacy of therapeutic interventions and having a deeper phenotyping of motor disabilities.
neck ROM	up to 6 weeks after enrolment	range of motion of the neck in x,y and z axis
bradykinesia evaluation	up to 6 weeks after enrolment	amplitude of repeated limb movements over time
tremor peak frequence	up to 6 weeks after enrolment	fourier analysis for peak frequence of tremor

Secondary Outcome Measures

Name	Time	Method
correlation with UPDRS gait Item	up to 6 weeks after enrolment	correlation of gait metrics with UPDRS gait score included.