Immunological characterization of peripheral blood samples inpatients with pulmonary cachexia

Recruiting

• Conditions: J44.9; C34.9; Chronic obstructive pulmonary disease, unspecified; Bronchus or lung, unspecified

• Registration Number: DRKS00034600
• Lead Sponsor: MU Klinikum, Medizinische Klinik und Poliklinik V

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-07-09
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

underlying disease currently assumed to be stable, no emergency treatment with hospitalization >24 h in the last 4 weeks
- no antibiotic or hematopoietic (G-CSF) treatment in the last 4 weeks
- patient is able to read and answer questionnaires
- patient is able to perform lung function and diffusion measurement
- Patient able to perform a hand force measurement

Exclusion Criteria

- patient age <18 years, patient not capable of giving informed consent
- unclear primary diagnosis (e.g.: suspected COPD, inclusion in the study can be reconsidered if the diagnosis is confirmed)
-severe known comorbidity associated with the development of cachexia, e.g. second malignancy, HIV infection (exception: concomitant COPD in NSCLC)
- Lack of weight gain during childhood development with a long-term low BMI <20 kg/m2
- known serious eating disorder, e.g. anorexia nervosa
- currently desired weight loss, e.g. as part of a diet
- anamnestic or documented Covid-19 infection within the last month
- pregnancy
- known critical anemia (Hb <8 g/dl)
- known high-grade cardiac arrhythmia
- known or documented allergy to nonivamide/nicobixil, as well as electrode patches
- after implantation of automatic, electronic devices, e.g. pacemakers
- after heart transplantation, lung transplantation

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Creation of a multimodal data set for comparative, explorative analyses of cachexia in COPD and NSCLC as a basis for a longitudinal follow-up study

Secondary Outcome Measures

Name	Time	Method
Identification of possible anamnestic and clinical predictors for the occurrence of cachexia in COPD and NSCLC