The effect of Oral BUtyrate on human Glucose and brownfAT metabolism

Completed

• Conditions: brown adipose fat tissue; insulin resistance; 10018424

• Registration Number: NL-OMON38772
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Group A; lean healthy males, age >18 years, BMI 18-25 m/kg
Group B: males, age> 18 years, BMI > 25 m/kg

Exclusion Criteria

Group A: smoking, use of medication, participation in a research protcol involving radiation exposure in the last 2 year.
Group B: smoking, use of medication, participation in a research protocol involving radiation exposure in the last 2 years.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Differences in BAT activity (semi quantitative uptake value of the tracer FDG<br /><br>visualised with PET-CT) as well as insulin sensitivity (clamps) </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Correlation between resting energy expenditure before and after using<br /><br>butyrate (4g/day, 4 weeks) during thermoneutral conditions.<br /><br>- Changes in fecal gutmicrobiota and fecal energy excretion (triglycerides).<br /><br>- Changes in subcutaneous gene and protein expression of insulin<br /><br>phosphorylation signalling pathways, inflammatory markers and lipid homeostasis<br /><br>pathways.</p><br>