Treatment Resistance Related With Gene Expression Profile of Diffuse Large B-cell Lymphoma
- Conditions
- Diffuse Large B-cell Lymphoma
- Registration Number
- NCT01606605
- Lead Sponsor
- Samsung Medical Center
- Brief Summary
The investigators perform a retrospective microarray gene expression profiling study of FFPE from a cohort of DLBCL patients with whole genome cDNA mediated Annealing Selection and Ligation (WG-DASL) assay. The investigators also study the pattern of microRNA from patients with diffuse large B-cell lymphoma. The results of gene expression profiles and microRNA is correlated with clinical outcomes of diffuse large B-cell lymphoma.
- Detailed Description
1. Whole genome cDNA mediated Annealing Selection and Ligation (WG-DASL) assay
* Diffuse large B-cell lymphoma patients
* Paraffin-embedded tissue
* End points: Progression-free survival, overall survival
* Statistics: Leave one-out method
2. Nano string assay for microRNA
* Diffuse large B-cell lymphoma patients
* Paraffin-embedded tissue
* End points: Progression-free survival, overall survival
* Statistics: Leave one-out method
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 350
- Patients diagnosed with diffuse large B-cell lymphoma
- Patients with tissue blocks available for study
- Patients with adequate medical records
- Patients diagnosed with other subtypes of lymphoma
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Number of patients who relapse or progress after 1st line chemotherapy two years
- Secondary Outcome Measures
Name Time Method Number and type of genes and microRNA which are significantly related with relapse or progression (P < 0.05) two years
Trial Locations
- Locations (1)
Samsung Cancer Research Institute
🇰🇷Seoul, Korea, Republic of