Abnormalities of B Lymphocytes During Systemic Lupus
Not Applicable
Completed
- Conditions
- Systemic Lupus Erythematosus
- Registration Number
- NCT00401141
- Lead Sponsor
- University Hospital, Strasbourg, France
- Brief Summary
Previous experimental data strongly suggest that B lymphocytes have intrinsic abnormalities during lupus in mice spontaneously affected by the disease. This study tries to define these abnormalities by looking at the gene expression profile of purified B lymphocytes from patients with non active systemic lupus , compared with the gene expression profile of purified B lymphocytes from healthy donnors.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Not provided
Exclusion Criteria
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms drive B lymphocyte abnormalities in non-active systemic lupus erythematosus as studied in NCT00401141?
How do gene expression profiles of B cells in SLE patients compare to healthy donors in longitudinal studies?
Which biomarkers correlate with B cell transcriptomic changes in non-active lupus for patient stratification?
What are the implications of B lymphocyte intrinsic defects in SLE for novel targeted therapies?
How does B cell dysfunction in NCT00401141 relate to autoantibody production in systemic lupus pathogenesis?
Trial Locations
- Locations (1)
Service d'Immunologie Clinique et VIH - Hôpital Civil
🇫🇷Strasbourg, France
Service d'Immunologie Clinique et VIH - Hôpital Civil🇫🇷Strasbourg, France