Influence of Thymoglobuline on Phenotypic and Functional Profiles of B Lymphocytes in Renal Transplant Recipients
- Conditions
- Renal Transplant
- Interventions
- Registration Number
- NCT02894606
- Lead Sponsor
- University Hospital, Brest
- Brief Summary
The investigators expect to better characterise B cell subpopulation and functional properties early after graft, to analyse effect of induction therapy (thymoglobulin versus basiliximab) on B cells, and to compare this B cell profiles with those obtained in our previous study in patients with chronic Antibody Mediated Rejection (cAMR)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- Age >18 years old
- Recipient of a renal allograft
- Patient receiving either basiliximab or thymoglobulin as in induction therapy for renal transplant
- Patient presenting a low immunologic risk
- Patient not opposed to his (her) study participation
Exclusion Criteria
- Patient participating in a clinical trial
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Thymoglobulin Induction Thymoglobulin Induction Patient receiving thymoglobulin as an induction therapy for renal transplant Basiliximab Induction Basiliximab Induction Patient receiving basiliximab as an induction therapy for renal transplant
- Primary Outcome Measures
Name Time Method The distribution of mature blood B cells subpopulations will be compared between the 2 groups one year after renal transplant Proliferation of freshly isolated cells T in presence of autologous B cells will be compared between the 2 groups. one year after renal transplant
- Secondary Outcome Measures
Name Time Method Serum B-cell activating factor (BAFF) concentration comparison between the two groups one year after renal transplant
Trial Locations
- Locations (2)
CHU Brest
🇫🇷Brest, France
Tours University Hospital
🇫🇷Tours, France