NCT02074111Unknown不适用
Moyamoya Disease Biomarkers in Patients With Intracranial Atherosclerotic Stroke
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Frequency of RNF213 gene variants and HR-MRI findings in patients with intracranial atherosclerosis
研究概览
简要总结
The aim of this study is to investigate the proportion of patients with moyamoya disease among the patients who were diagnosed as having intracranial atherosclerotic stroke. To do this, biomarkers (gene and imaging) for moyamoya disease are tested and follow up angiography are performed during follow up (in selected patients).
详细描述
- Purpose Both moyamoya disease (MMD) and intracranial atherosclerotic stenosis (ICAS) are more prevalent in Asians than in Westerners, although the reason for the race-ethnic differences is unsettled. It is possible that patients with adult-onset MMD were misclassified as having ICAS, which may in part explain the high prevalence of intracranial atherosclerosis in Asians. It is important to differentiation between these two diseases because MMD and ICAS have differential therapeutic strategies (surgical revascularization in MMD vs. the use of antithrombotics/statins and stenting in ICAS). The ring finger 213 (RNF213) was recently identified as a susceptibility gene for MMD in East Asians. Characteristic high-resolution (HR) MRI findings of MMD and ICAS have recently been reported. The aim of this study is to investigate the proportion of patients with moyamoya disease among the patients who were diagnosed as having intracranial atherosclerotic stroke. To do this, biomarkers (gene and imaging) for moyamoya disease are tested and follow up angiography are performed during follow up (in selected patients).
- Conditions: Stroke, intracranial occlusive lesion
- Intervention: None
- Study period: Jan 22, 2014 ~ Dec 31, 2016
- Study design: Observational model Time perspective: Retrospective-Prospective
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Intracranial atherosclerotic stroke
- •Patients with age over 20 years
- •Patients with focal neurological deficits presented within 7 days of symptom onset
- •Patients with acute ischemic lesions on diffusion-weighted image (DWI)
- •Patients with stenosis on the relevant intracranial vessels (distal ICA and/ or M1)
- •Moyamoya disease
- •Patients with age over 20 years
- •Patients who performed conventional angiography
- •Patients who are diagnosed as having either definite or probable Moyamoya disease
- •Healthy subjects
- •Subjects with age over 20 years
- •Subjects with no history of cerebrovascular disease
排除标准
- •Patients with extracranial stenosis more than 50%
- •Patients with potential sources of cardio-aortic embolism
- •Patients with moderate to severe renal disease
- •Pregnancy or lactation
- •Patients with short life expectancy
结局指标
主要结局
Frequency of RNF213 gene variants and HR-MRI findings in patients with intracranial atherosclerosis
时间窗: Anytime during study period (in intracranial atherosclerosis, HR-MRI findings within 2 weeks)
次要结局
- Frequency of typical angiographic findings of moyamoya disease at follow up conventional angiography in patients with intracranial atherosclerosis who showed typical gene and imaging biomarkers of moyamoya disease(Within 2 years)
研究者
Oh Young Bang
Associate Professor
Samsung Medical Center
研究点 (1)
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