The central mechanism of acupuncture for the patients with knee osteoarthritis: study protocol for a randomized controlled trial
- Conditions
- Knee osteoarthritis
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
1. Male or female, aged 45–75 years;
2. Following the diagnostic criteria of knee osteoarthritis, and Right-handed;
3. Good compliance and willing to cooperate with the research;
4. Radiologic confirmation of knee osteoarthritis (Kellgren–Lawrence grade I-III);
5. The informed consent form was signed by the patient or by their immediate family members.
1. Complicated with other knee joint diseases, such as tuberculosis, tumor, rheumatism and rheumatoid arthritis; 2. Complicated with sprain, contusion or other trauma, foot deformity, pain and other diseases affecting normal walking;
3. Patients with severe cardiovascular disease, damage of liver and kidney function, immune deficiency, diabetes mellitus, and blood disease;
4. Severe drug and alcohol dependence, mania or schizophrenia;
5. Patients with obvious headache, migraine, dysmenorrhea and other chronic pain diseases, history of head trauma;
6. Be insensitive to pain due to advanced diabetes, neuropathy or use of strong painkillers;
7. have knee pain caused by radiculopathy/herniation of an intervertebral disc;
8. Have a history of prolotherapy, hyaluronic acid injections or corticosteroids injections within 3 months;
9. have received acupuncture, electro-acupuncture, Tui-na therapy, massage, or physiotherapy 8 weeks prior to enrolment in the trial;
10. Have MRI contraindications such as claustrophobia, cardiac pacemaker, defibrillator, heart stenting, or intrauterine device.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Western Ontario and McMaster University Osteoarthritis Index scores;
- Secondary Outcome Measures
Name Time Method Baker anxiety scale (BAI);The pain visual analogue scale (VAS);Baker Depression scale (BDI);Arthritis Quality of Life Measurement Scale Simplified Scale (AIMS2-SF);The Chinese version of the modified Massachusetts General Hospital Acupuncture Sensation Scale (C-MMASS)The Chinese version of the modified Massachusetts General Hospital Acupuncture Sensation Scale (C-MMASS);Knee Injury and Osteoarthritis Outcome Score, KOOS;