The effect of fractional CO2 laser in combination with topical insulin in treatment of facial atrophic acne scars

Not Applicable

Not yet recruiting

Conditions: Acne vulgaris,

Registration Number: CTRI/2025/05/086346

Lead Sponsor: IMS AND SUM HOSPITAL

Brief Summary: This is a randomized split-face study that includes 30 atrophic post-acne scar patients meeting the inclusion and exclusion criteria, visiting the IMS and SUM Hospitals skin VD OPD. On each visit, pre- and post-procedure photographs along with grading of acne scars are done, and fractional CO2 with topical insulin on one side of the face is given, decided by computer-generated randomization, and fractional CO2 laser with topical normal saline is given on the other side of the face. Pre and post-procedure blood sugar levels are recorded, and post-procedure erythema and post-inflammatory hyperpigmentation scores are done on each visit

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 30

Inclusion Criteria

Atrophic post Acne scar of any grade Fitzpatrick skin type 3 to 6 No treatment (including surgical and laser therapy) within 12 weeks before being enrolled in the study.

Exclusion Criteria

Pregnancy and lactation Autoimmune disease, connective tissue disease History of Photosensitivity Use of immunosuppressive medications, active cancer, underlying illness (cardiac, neurological) History of skin cancers, and presence of premalignant or malignant cutaneous lesions over the face.
History of keloidal tendency Patient on isotretinoin therapy Presence of hypertrophic scars History of diabetes mellitus.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To Compare the efficacy of topical insulin with fractional CO2 laser versus fractional CO2 alone in the treatment of PAS.	0 week,4 weeks,8 weeks,12 weeks

Secondary Outcome Measures

Name	Time	Method
To Assess the safety of topical insulin with fractional CO2 laser in the treatment of PAS.	To Assess the effect of topical insulin with fractional CO2 laser therapy on the quality of life in PAS patients

Trial Locations

Locations (1): IMS AND SUM HOSPITALS
🇮🇳
Khordha, ORISSA, India
IMS AND SUM HOSPITALS
🇮🇳Khordha, ORISSA, India
Dr Bikash ranjan kar
Principal investigator
9937428181
bikashkar@soa.ac.in