Respiratory Muscle Strength in Rheumatoid Arthritis

Recruiting

Conditions: M06
Other rheumatoid arthritis

Registration Number: DRKS00027879

Lead Sponsor: ungenklinik, Kliniken der Stadt Köln gGmbH

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 72

Inclusion Criteria

Rheumatoid arthritis patients = 18 years of age who are able to give informed consent are included in the study. The diagnosis of RA must have been made according to the guideline ACR/EULAR criteria from 2010.
For data collection and later analysis, rheumatoid arthritis patients will be divided into the above 3 categories.

Control group:
Healthy subjects, age =18 years; no symptoms of muscle disease; no history of rheumatologic disease or muscle disease;
Subjects will be asked not to undergo exhaustive physical exertion, smoke or consume large amounts of alcohol 24 hours before the examination.

Exclusion Criteria

Exclusion criteria both groups:
Specific pre-existing conditions: Chronic alcohol abuse, neuromuscular disease, COPD, severe heart failure (with an ejection fraction (EF) = 40%) diaphragmatic paresis, pulmonary hypertension, uncontrolled bronchial asthma, diabetes mellitus with polyneuropahtia; active malignancy, hypoventilation syndrome, obesity with BMI = 35kg/m² or an exacerbation of rheumatoid arthritis or other underlying disease.
Before ordering the 6-minute walk test, the medical staff must check whether there is an increased risk of falls for the patient. If this is the case, it is considered a criterion for exclusion.
Medication in the last 12 months: Therapy with oral corticosteroid within the last 12 months to an extent that could affect muscle strength.
Drug use
<18 years of age
Inability to consent

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Is there a reduction in respiratory muscle strength measured by peak inspiratory mouth closure pressure (PImax peak = primary endpoint) as an expression of global respiratory muscular strength in rheumatoid arthritis patients:irrespective of the stage of their disease compared to healthy individuals.

Secondary Outcome Measures

Name	Time	Method
A) Comparison between patient group and control group.<br>- Other respiratory muscular function parameters <br>- Hand muscle strength<br>- Lung function parameters <br><br>B) Influence of functional parameters (lung function, respiratory muscle function, hand muscle strength) on clinical patient-relevant outcomes. <br><br>C) Comparison of the patient group and in the control group<br>- Relationship between respiratory muscle strength and hand muscle strength