To elucidat the pain mechanism in rotator cuff tear by conmapizon in the expression got paen related substances betwenn rotator cuff tear and chronic anterior shoulder instabilitu
Phase 1
Recruiting
- Conditions
- rotatorr cuff tear and anterior shoulder instabilty
- Registration Number
- JPRN-UMIN000041077
- Lead Sponsor
- Kitasato University School of Medicine
- Brief Summary
COX-2: no significant difference between rotator cuff tear (RCT) and repetitive shoulder dislocation (RSD) NGF: significantly elevated in RCT group Significant correlation between pain score and NGF expression APELIN: significantly elevated in RCT group Significant correlation between pain score and expression of APELI
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Not provided
Exclusion Criteria
patients with frature around shoulder. patients with RA or systemic inflammatory disease patient treated with sterorid with in 1 month before operation.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical score at before operation (Constant score, UCLA scale, Simple shoulder scale, VAS of pain) Range of Motion (Flexion, Abduction, External rotation, Internal rotation) mRNA level (TBF-alpha, IL-1beta, COX-2, NGF, Apelin NPFF, IL-6)
- Secondary Outcome Measures
Name Time Method