"Normal Coronary Artery" With Slow Flow Improved by Adenosine Injection, Dipyridamole Treatment and Clinical Follow-up

Early Phase 1

• Conditions: Coronary Angiography
• Interventions: Drug: Statin, aspirin; Drug: Dipyridamole

• Registration Number: NCT00960817
• Lead Sponsor: Hillel Yaffe Medical Center

Brief Summary

The investigators will investigate patients undergoing coronary angiography with normal coronary but slow blood flow that was normalized after adenosine injection into the coronary artery. The investigators believe that they have small vessel coronary disease which is the initial presentation of coronary disease prior to anatomical narrowing. To alleviate this phenomenon the investigators intend to examine the long-term clinical response of these patients to treatment with dipyridamole, a well-known medication with almost no side-effects that increases the level of adenosine in the tissue.

Detailed Description

Not available

Study Timeline

• Status Verified: 2009-08
• Study First Submitted: 2009-08-17
• Study First Submitted QC: 2009-08-17
• Last Update Submitted: 2009-08-17
• Study First Posted: 2009-08-18
• Last Update Posted: 2009-08-18

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Patients undergoing coronary angiography and who have normal coronary artery with slow blood flow that normalized with adenosine injection into the coronary artery

Exclusion Criteria

• Significant coronary disease
• Unstable patients
• Patients with known sensitivity to dipyridamole

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
1. Routine treatment	Statin, aspirin	Control group
2. Dipyridamole treatment	Dipyridamole	Group that receives Dipyridamole treatment

Primary Outcome Measures

Name	Time	Method
Alleviation of chest pain	Two years

Trial Locations

Locations (1)

Hillel Yaffe Medical Center; 🇮🇱 Hadera, Israel