Non-invasive Diagnosis of Coronary Artery Stenoses by Doppler Echocardiography

Not Applicable

Completed

• Conditions: Stable Angina Pectoris; Unstable Angina Pectoris; Acute Myocardial Infarction
• Interventions: Procedure: Doppler echocardiography

• Registration Number: NCT00281346
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

Non-invasive evaluation of patients with stable angina and unstable coronary syndromes with transthoracic Doppler echocardiography to evaluate presence of significant coronary stenoses. Blinded evaluation and comparison with coronary angiography: presence and location of stenoses, and head to head comparison of clinical value and patient classification.

Detailed Description

Transthoracic Doppler echocardiographic evaluation with extensive evaluation of coronary stenoses in all 3 main branches using colour flow, pulsed Doppler and Coronary flow velocity reserve (CFVR)after pharmacologic stress with adenosin in the area of LAD and RDP. Blinded evaluation of Doppler results and coronary angiography regarding the other examination modality. Coronary angiography diagnostic "gold standard". Only stable and unstable patients otherwise scheduled for angiography on clinical reasons will be examined and included in the study.

Added January 2007 after ethics committee approval: comparison of CFVR with invasive fractional flow reserve (FFR) in selected subset of patients.

Study Timeline

• Study Start: 2005-12
• Study First Submitted: 2006-01-23
• Study First Submitted QC: 2006-01-23
• Study First Posted: 2006-01-24
• Primary Completion: 2008-01
• Study Completion: 2008-08
• Status Verified: 2016-07
• Last Update Submitted: 2016-07-15
• Last Update Posted: 2016-07-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 110

Inclusion Criteria

• unstable angina or acute myocardial infarction, or stable angina pectoris and
• scheduled for coronary angiography on accepted clinical reasons

Exclusion Criteria

• past coronary artery grafting

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
transthoracic Doppler echocardiography	Doppler echocardiography	-

Primary Outcome Measures

Name	Time	Method
pr patient evaluation	Inhospital
Diagnostic yield: Accuracy, positive and negative predictive value.	Inhospital

Secondary Outcome Measures

Name	Time	Method
pr stenosis evaluation	Inhospital

Trial Locations

Locations (1)

Ålesund Hospital HF; 🇳🇴 Ålesund, Norway