Could Non-invasive Biochemical, Image or Physiological Index Predict Significant Coronary Arterial Stenosis in Symptomatic Adults?

• Conditions: Coronary Heart Disease
• Interventions: Radiation: coronary calcium score measurement; Biological: high sensitivity C reactive protein measurement; Procedure: ankle brachial index measurement

• Registration Number: NCT01645228
• Lead Sponsor: Cathay General Hospital

Brief Summary

To validate the capability of non-invasive bio-image tests in prediction of significant coronary stenosis of symptomatic adults.

Detailed Description

The main objective is to validate the capability of these non-invasive tests (CCS, hs-CRP and ABI) in prediction of significant coronary stenosis of symptomatic adults. The end-point will be the findings of coronary CT angiography. The investigators hope the results of our study could be applied on the interpretation of health examination and the advice of follow-up and therapy.

Study Timeline

• Study First Submitted: 2012-07-18
• Study First Submitted QC: 2012-07-19
• Study First Posted: 2012-07-20
• Status Verified: 2012-08
• Study Start: 2012-08
• Last Update Submitted: 2012-08-14
• Last Update Posted: 2012-08-16
• Study Completion: 2013-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• subjects for a general health check-up protocol, which included CACS and CCTA, and biochemical measurements (total cholesterol, total triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, high sensitivity C reactive protein)

Exclusion Criteria

• anyone allergy to iodine contrast medium, unable cooperation for CT scanning, asymptomatic

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
significant coronary artery stenosis	coronary calcium score measurement	anyone coronary segment \> 50% diameter stenosis
significant coronary artery stenosis	high sensitivity C reactive protein measurement	anyone coronary segment \> 50% diameter stenosis
significant coronary artery stenosis	ankle brachial index measurement	anyone coronary segment \> 50% diameter stenosis

Primary Outcome Measures

Name	Time	Method
coronary CT angiography	within one month

Trial Locations

Locations (1)

Cathay General Hospital; 🇨🇳 Taipei, Taiwan